Abstract

Background: Ameloblastoma is a rare, asymptomatic, aggressive, slow growing, benign odontogenic tumor arising from the residual epithelium of tooth germ, lining of odontogenic cysts and enamel organ. occurring primarily in the lower jaw. They represent 1% of all jaw tumors. Ameloblastomas show a locally aggressive behavior, rarely associated with a malignancy. They are the second most common odontogenic tumor after odontomas. Almost 80% of the cases are seen in mandible while as the rest are seen in the maxilla. Methods: A comprehensive literature search was conducted to identify relevant studies. Different database and search engines were explored, PubMed, Scopus, Google Scholar, Web of Science, Indexed Copernicus. The search strategy employed a combination of keywords like ameloblastoma, intracranial ameloblastoma, ameloblastoma of brain. The search was limited to English language studies. Results: Although a rare entity, Intracranial Ameloblastoma when encountered is associated with the poor prognosis. Major factor involved in progression of ameloblastoma to brain is its aggressive nature and recurrence. Conclusion: Ameloblastoma is highly invasive and rarely infiltrate base of skull, infratemporal fossa, paranasal sinus, pterygopalatine fossa, orbit and paraphyrangeal space. The intracranial spread of ameloblastoma is a rarely detected condition but its knowledge can save lives of many patients.