Abstract

Diabetes mellitus, a chronic ailment, frequently associated with permanent and irreversible functional and structural changes in the body cells, with around 422 million sufferers worldwide. Succour in the use of products having anti-diabetic activity of better performance with less toxicity and cost is being sorted. Researchers worldwide have long been encouraged to intensify efforts in the search for more effective treatment remedies, notwithstanding there exist already available hypoglycaemic agents and insulin. Many researchers are joining this research quest to avail for the best treatment agent so as to control the frequent disease corollaries. The experimental model of a disease aids the understanding of the pathophysiology of the disease and the development of drugs for its management. The ease of handling rodents makes their use most appropriate for research purposes. There are genetically engineered rodents, as well as other rodent models such as chemical (streptozotocin, alloxan, and Ferric nitrilotriacetate) which has gained much use amongst scientists in this hub because of affordability, availability, and ease with use, an advantage of low income researchers in resource poor economy (African institutions). The cumbersome effort in trying to decide on the method and chemical of choice in traversing this research area gave the need for a wide review of researches carried out spanning from 1975 to 2023. The criteria to be used forinclusiveness being: The frequency of use of the chemical; The most frequent dose and route of administration employed; The ease of the administration in terms of technique following the advanced search using these words ‘’chemical method of diabetes induction in rodents(NOT reviews)’’ spanning from 1975 to September 2023. The search engines employed were Base; PubMed; Google scholar; World cat search and Science direct. The most frequently engaged chemical methods remains, streptozotocin and alloxan induction respectively. The preferred route/ dose for streptozotocin for chemical induction are Intraperitoneal/ 35- 65mg/kg; and Alloxan Intraperitoneal/ 70-170mg/kg.