Abstract

Background: Endocrine disorders encompass a wide range of conditions affecting hormone secretion and function, with significant impacts on health and well-being. Emerging research suggests a pivotal role of the gut microbiota in modulating endocrine pathways, thereby influencing the development and progression of various endocrine disorders. Objective: This review aims to elucidate the mechanisms through which gut microbiota influence endocrine disorders and explore potential therapeutic interventions targeting the gut microbiome. Materials and Methods: A comprehensive literature search was conducted using electronic databases including PubMed, Google Scholar, and Web of Science. Keywords such as "gut microbiota," "endocrine disorders," "mechanisms," and "therapeutic implications" were utilized to identify relevant studies. Articles published up to January 2024 were included in this review. Conclusion: The gut microbiota plays a crucial role in modulating endocrine function through various mechanisms including immune modulation, metabolism regulation, and neuroendocrine signaling. Dysbiosis of the gut microbiota has been associated with the pathogenesis of endocrine disorders such as obesity, diabetes, and thyroid dysfunction. Understanding the intricate interplay between gut microbiota and endocrine pathways opens avenues for novel therapeutic strategies including probiotics, prebiotics, and fecal microbiota transplantation. Further research is warranted to elucidate specific microbial targets and optimize therapeutic approaches for the management of endocrine disorders.