Abstract

Objectives: The aim of current study was to design and evaluate different formulations of topical gel containing clarithromycin (CLR) and lactic acid for the treatment of acne and acne scar. The gel was formulated using different concentrations of cabopol-934, propylene glycol and optimized for variable i.e. starring speeds and temperature conditions etc. Five different formulations were prepared and characterized for pH, colour, drug content, spreadability, homogeneity and viscosity. FTIR and DSC of formulation were carried out to confirm drug-excipients compatibility.

Result: The drug content of the formulation was found to be 97.78±0.55%; In-vitro drug release study was performed using Franz diffusion cell and was found to be 98.19±2.43 % in 60 min. and showed the good anti-acne efficacy.

Conclusion: Formulation showed good spreadability, consistency, homogeneity and antibacterial activity indicating its suitability for topical use for acne treatment.