Abstract

Burst suppression is an EEG (electroencephalograph) pattern that can be observed when patients are under the influence of general anesthetics, in severe conditions such as cerebral anoxia, or rare epileptic encephalopathies, like Ohtahara syndrome, which manifest in the neonatal period. We present a child with a de-novo mutation of SNAP25 and a burst suppression pattern that persisted after the neonatal period. The patient has a history of seizures and a global developmental delay since infancy. Her EEG in the neonatal period demonstrated hypsarrythmia and burst suppression, and the burst suppression pattern continues to be present at four years of age. We suggest that the SNAP25 mutation of the patient is the likely cause of the burst suppression EEG pattern.