Interlukin-4 (IL-4), Tumor Necrosis Factor-α (TNF-α), and its receptors Gene Polymorphism in Type 2 Diabetes Mellitus
Authors:
Alhazmi AS, Al Omari A, Hussein YM, El Askary A, Damiati L
Author Affiliations
Alhazmi AS Clinical Laboratories Department, Faculty of Applied Medical Sciences, Taif University, Saudi Arabia Email:
aboteef999@hotmail.com
Al Omari A Clinical Laboratories Department, Faculty of Applied Medical Sciences, Taif University, Saudi Arabia
Hussein YM Clinical Laboratories Department, Faculty of Applied Medical Sciences, Taif University, Saudi Arabia & Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Egypt
El Askary A Clinical Laboratories Department, Faculty of Applied Medical Sciences, Taif University, Saudi Arabia & Medical Biochemistry Department, Faculty of Medicine, Al Azhar University, Egypt
Damiati L Medical Laboratories Department, Prince Mansour Military Hospital, Saudi Arabia
Type 2 diabetes mellitus (T2DM) and its complications become a major cause of inactivity and death worldwide. The immune system plays a significant role in the development and complication of T2DM. Cytokines and its receptors were a major part of the immune system involved in T2DM complications. Recently, genetic factors become a focused area to evaluate the contribution of these cytokines with diabetes. Subjects and methods: 150 T2DM patients and 100 healthy males were recruited into Prince Mansour specialized hospital. For each individual, serum glucose, cholesterol, triglyceride, HDL-C, urea, creatinine, TNF-α, and IL-4 were measured for all individuals included in this work. TNF-α (-308G/A) and (-238G/A), TNFRII (M196R), IL-4 (-590C/T), and IL-4Rα (I50V) gene polymorphism were detected. Results: TNF-α and IL-4 levels were elevated in T2DM patients (P
Keywords
Type 2 diabetes mellitus; Polymorphisms; Cytokines; IL: Interleukin