Abstract

Lemierre’s syndrome is a rare but life-threatening condition characterized by septic thrombophlebitis of the internal jugular vein, often following oropharyngeal infections such as pharyngitis. Prompt diagnosis is crucial because early intervention with appropriate antibiotic therapy can significantly reduce morbidity and mortality. Diagnosis is typically confirmed through contrast-enhanced CT imaging and blood cultures, with Fusobacterium necrophorum being the most commonly isolated pathogen. Treatment involves prolonged antibiotic therapy targeting anaerobes, typically for 4-6 weeks, and sometimes surgical drainage of abscesses. Although the role of anticoagulation is still debated, it may be indicated in cases with thrombus progression or persistent infection. Early recognition and aggressive management are key to improving outcomes and preventing fatal complications.