Abstract

Metribuzin is an herbicide belonging to the triazinone group, which is incorporated as a weed killer in wheat, potatoes, tomatoes, etc. The aim of this study was to evaluate the effect of metribuzin as a cause of cardiovascular disease. Human exposure to Metribuzin occurs through inhalation and ingestion, usually in agricultural settings. However, few studies have evaluated population exposure to this herbicide. Metribuzin can accumulate in soil and water and cause damage to plants and animals. Furthermore, the herbicide metribuzin has a highly variable toxicity, in the short term it can cause acute poisoning that can cause difficulty in breathing and drowsiness but high exposures can cause various cardiovascular pathologies including coronary heart disease (CHD), cerebrovascular disease, peripheral arterial disease, rheumatic and congenital heart diseases, and venous thromboembolism. Some organophosphate compounds, such as diazinon, can trigger oxidative stress in the cardiovascular system. Accordingly, it is necessary for farmers to avoid its use and replace it with biological fertilizers that are less harmful to human and animal health.