Abstract

Serine proteases, a class of enzymes that play physiological role in digestion, blood coagulation, and immune response We sought to find the relation of serine proteases and level changes based on demography in patients with kidney failure compared to a control group. By evaluating 160 samples, comprising 80 from individuals with renal failure and 80 from healthy controls, the researchers observed a significant elevation in serine protease activity among kidney failure patients (274.38 ± 1.55 U/L) relative to the control group (173.78 ±1.49 U/L). Importantly, this enzyme’s activity was unaffected by sex or smoking, though body mass index demonstrated age-related variability across both cohorts. These comprehensive findings underscore the profound metabolic disruptions inherent to kidney failure while providing pivotal insights into enzyme activities and mineral imbalances associated with this condition.