Introduction: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, often associated with metabolic abnormalities, including dyslipidemia, insulin resistance, and obesity. The aim of the study was to evaluate the effects of inositol supplementation on lipid profile parameters in PCOS patients.
Methods: With 100 participants, a case-control study was carried out separating a control group following a healthy diet from a case group using myo-inositol plus D-chiro-inositol (2000 mg daily). Lipid profiles were assessed at the beginning and after 8 weeks.
Result: The case group displayed considerable declines in triglycerides (14.6%, P < 0.001), total cholesterol (22.3%, P < 0.001), and low-density lipoprotein cholesterol (7.1%, P = 0.013). Although not statistically significant, there is a slight decrease observed in high-density lipoprotein cholesterol (HDL) levels (p = 0.058).
Conclusion: inositol may effectively improve lipid profiles in PCOS patients, supporting its potential as a therapeutic option for managing metabolic disturbances associated with the condition.