Background: Lower extremity discomfort is the main proven manifestation of venous thrombosis (VT) plus core illness in specific patients with early Parkinson’s disease (PD). Once VT triggers pulmonary embolism, the blood-clot probably may risk the PDs lifespan. Objective: Thus we researched the occurrence of deep-vein thrombosis (DVT) plus its likely correlation though clinical and/or diagnostic research lab-types. Methods: With ultra-sonography, within 117initial-stage Parkinson`s, 11(9.4%) cases noticed through DVT + 106(90.6%)without DVT (Figures 1 & 2). difference shown (Figure 3). Not many changes linking the cases by DVT and not by DVT in gender, body-mass-index, smoking and drinking habits, hypertension, diabetes, sugar history of ‘atrial-fibrillation’, tumor, also lab tests connected with VT. Parkinson`s through the DVT were by elder ages plus excessive levels of d-dimers.
Results: The echo region of right-side substantia nigra ultrasound in Parkinson`s by DVT was drastically spread, however, there was no sizable variation in left-side. Besides, Parkinson`s through the DVT ensured greater stage H and Y grades and UPDRS-III scores, whereas open stage UPDRS-III scores and cognition >5 and levodopa had lower rates of progression in UPDRS-III. The dose of levodopa for treatment within Parkinson`s through DVT was much reduced. Age duration, D - d dimer levels, plus lowdose levodopa were key risk-factors for lower-extremity venous thrombosis. In elderly and early Parkinson`s, it is essential to do d - dimer and lower-extremity vascular-ultrasound tests. Prevention of VT of the minor-extremities Parkinson`s is particularly beneficial. Correlation by level of d-d dimer in medroxyprogesterone-test showed in (Figure 4) but no significant correlation amid age+LED concentration (Figure 5). Table1 summarizes significant reduction by levodopa. Table2, 3, and 4 is Binary logistic regression analysis in relation to LEVT about history, examinations, drugs and its efficacy.
Conclusion/clinical significance: we recommend that for initial-phase Parkinson`s, D - dimer + lower extremity vascular ultrasonography is good for aged (elderly>65) patients. Initial imaging/screening-test, timely discovery, promptly-prognosis +early clinical management are most significant for early-stage patients to thwart the progression of lesser-extremity VT, which could avert the occurrence of cancerous outcomes.