Abstract

Objectives: Low levels of blood vitamin D have been reported not only in children with otitis media and frequent respiratory tract infections, but also in PFAPA syndrome patients. Levels of vitamin D are influenced regional and racial differences. The objective of this scientific literature review was to inspect whether people who live in countries with cold climates have a high demand for vitamin D supplementation; to know the population that requires vitamin D supplementation; to identify the countries that are most demanding for these vitamin D interventions; and to verify the appropriate duration of a successful intervention. For this, a systematic review was carried out under the PRISMA declaration, where 21 articles out of 207 were included, found in the PubMed, SciELO, and gray literature databases. In summary, the effective interventions were carried out mainly in homes, and with a duration equal to or less than 6 months, and it was possible to realize that the male population is the most likely to suffer from vitamin D deficiency.