Abstract

Introduction: Fibromyalgia is one of the most frequent pain syndromes, and constitutes a real therapeutic challenge, for which a multimodal and multidisciplinary approach is necessary. In recent years, expectations have grown regarding the possible efficacy of cannabis as part of the adjunctive management in this pathology. Objective: Prepare a narrative review regarding the evidence that exists on the safety and efficacy of medicinal cannabis in the pharmacological management of fibromyalgia.

Methods: A research was carried out on the scientific evidence available in databases (Pubmed/ Medline, Science Direct, Scielo, Cochrane, BioMed Central) using the terms “(cannabis OR cannabinoids) AND fibromyalgia”, to develop a narrative review of the literature. Results: The initial search resulted in a total of 144 titles. After the exclusion process, only 11 articles were relevant for the narrative review of this article.

Conclusion: Despite the promising evidence, more research is needed to determine the clinical benefits, the required dose, the ideal route of administration and composition, and the tolerability profiles of the different cannabinoids in the management of fibromyalgia.