Abstract

Immune thrombocytopenia purpura (ITP) is a disorder characterized by decreased platelet production and degradation. Recently, 1,25[OH]2D3 has been known as an immune modulator. The purpose of our study was to assess the relationship between 1,25(OH)2D3 levels and ITP based on sex, age and duration of disease. The present study was retrospectively conducted by reviewing medical records of the ITP patients. Demographic data including age, sex, and disease history and serum vitamin D levels was extracted and collected in a pre-designed form. Data was reported as Mean ±SD and as frequency (percentage). Independent T-test or ANOVA test was used to compare the mean serum levels of vitamin D based on sex, age or disease history. Subjects enrolled into the study were 140, they were 71 females and 69 males with mean age± SD of 39.90 ± 16.11 years which 87(62.14%) of them in acute and 53(37.86%) of them were in chronic phase of the disease. The mean serum vitamin D level in patients was 18.85 ± 10.87. There was no significant relation between sex and serum vitamin D level (P = 0.943). Patients in the range of 30-40 years have the most frequency and the lowest level of vitamin D in serum (17.11± 9.68). There was no relation between age and vitamin D based on Pearson’s test (p=0.181). Vitamin D level in acute ITP patients was lower than chronic ITP patients, but this difference was not meaningful (p=0.403). According to the findings of this study, it is an interesting area of research that vitamin D can be administered as a new immunomodulatory therapy in patients with ITP.