Abstract

The study included examination of 45 children born after ARTs and 20 controls, which involved assessment of health status, presence of congenital developmental abnormalities, as well as data of neonatal history, to look for association with genetic developmental abnormalities of enzymes of antioxidant defense superoxide dismutase (SOD), catalase (CAT), as well as hypoxiainducible factor (HIF). The study data showed relationship between incidence of some diseases with presence of mutation in these genes. Occurrence of heterozygous forms of these enzymes was associated with features of diseases found in subjects’ histories: for SOD functional disturbances of digestive system (2.2 ± 2.2 %) r = 0.42, minor heart development abnormalities (11.1 ± 4.7 %) r = 0.34, atopic dermatitis (4.4 ± 3.1 %); for CAT urinary system diseases (42.1 ± 11.3 %), functional disorders of biliary tract (21.1 ± 9.4 %), minor heart abnormalities (52.6 ± 11.5 %), recurrent respiratory diseases (63.2 ± 11.1 %), retardation of physical (10.5 ± 7.0 %) and neural and mental development (21.1 ± 9.4 %), diseases of auditory and visual systems (21.1 ± 9.4 %); for HIF-1 minor heart abnormality (72.7 ± 13.4 %), signs of undifferentiated dysplasia of connective tissue (18.2 ± 13.4 %), manifestations of atopy (27.2 ± 13.4 %).