Abstract

A single blind comparative clinical study was done in order to evaluate the effectiveness of an external application of ointment which was prepared from seed powder of Pongamia Pinnata. Two different concentrations, 5% and 10%, of the drug were prepared. Patients were selected from the outdoor patient division, Rural Siddha Ayurvedic Hospital, Kobalapuram. Thirty patients with bilateral involvement of the lesions were selected for the survey and categorized each to the Test 1, Test 2, Standard and Control groups respectively, such that 15 lesions were included in each group. Ointment prepared from the seed power of P. pinnata was given to apply twice a day on the selected lesion in the test groups. Observation was done after two weeks and follow up week. At the end of the treatment, P- value for skin pigmentation reduction T1 and T2 were 0.003 and 0.000 respectively indicating that significant improvement was achieved compared to the control group (P-value of 0.104). The P- values for the area size difference of the two groups were 0.001 and 0.001 respectively. It shows the effectiveness of the area reduction of both groups were significant and same. But the P-value for the control group was 0.153 and it implies an increase of the lesion area. So the improvement of the pigmentation reduction of the lesion and reduction of area size can be seen with the external application of the ointment prepared from the seed powder of P. pinnata.