Abstract

Diseases involve different biological processes and exhibit different pathophysiological states at different time points, so there should be different biomarkers at different stages. Urine is an ideal disease biomarker source. As it is not under the control of homeostatic mechanisms, urine can theoretically reflect pathological changes in a sensitive and timely manner. Could urine biomarkers reflect different stages of disease? In the current review, we summarised the results of urine biomarkers at different time points in various animal models of disease. We believe that urine biomarkers at different time points can also reflect different states of human disease. More importantly, urine can reflect systemic changes in the whole body, so studying urine biomarkers at different time points provides clues to explore unknown pathogenesis and to find targets for drug intervention.