Abstract

Pyrimidine plays an important role in several biological processes. An early metabolite prepared was 5-fluorouracil (5-FU). The biological profiles of this new generation of pyrimidine represent good progress with regard to the older compounds [2]. A pyrimidine derivative followed by 5-thiouracil also exhibits some useful antineoplastic activities. Also they are used as building blocks in pharmaceutics for the synthesis of nucleoside antibiotics, antiviral, antibacterial, and antifungal agents.