Abstract

Acute encephalitic syndrome (AES) though primarily caused by virus but other pathogens cannot be ignored as prompt and correct clinical acumen save majority of life. Treatment and evaluation of 147 cases of AES admitted at our centre managed based on previous experience of similar AES prevalence in 1985, in nutritionally deprived patients of poor socio economic status with history of passing Round worm, saved all 147 cases without any adversity or adjuvant required or mortality and all passed round worm on deworming (Albendazole & Ivermectine ) in therapeutic dose for 3 consecutive days after 7th day of discharge. Majority patients regained consciousness within 48 hours of therapy while seizure seized in all cases by 12 hours of therapy. Thus consider Round worm Encephalopathy in nutritionally deprived patients of AES in addition to other pathogens as right approach will save life, time and cost of therapy. Round worm causes encephalopathy due to competitive inhibition of Pyridoxal 5 phosphate Co enzyme, a prime co enzyme for Gama Amino Butyric Acid synthesis and metabolism in brain by its poly peptide secretion in adverse situation.