Abstract

Background: Reports on clinical uses of platelet-rich plasma (PRP) have dramatically increased in the last decade. Indications for PRP therapy range from muscle and skeletal injuries to hair re-growth. More recently evidences have shown its positive effects in promoting endometrial and follicular growth and gestation in assisted reproduction cycles. We discuss the alleged role of PRP on endometrial receptivity and ovaries rejuvenation with a brief history of its applications in research and clinical therapies. Methods: This report presents the cases of 3 womens aged 34,41,41 who have experienced premature menopause or POF. Having rejected oocyte donation, they opted for intraovarian injection of autologous platelet-rich plasma with the aim to rejuvenate the ovarian tissue and enable the employment of her own gametes through in-vitro fertilization. Weeks following the autologous platelet-rich plasma treatment, a significant reduction in the patient’s follicle-stimulating hormone (FSH) levels was noted. Discussion: A natural in-vitro fertilization cycle and natural conception led to a biochemical pregnancy. This is a report of a successful autologous platelet-rich plasma application leading to pregnancy in menopause or POF. This report has a unique contribution to the medical knowledge and challenges current practice in the context of infertility. Conclusion: Despite its widespread uses in medicine, the mechanisms through which PRP exerts its regenerative effects are only postulated, not based on scientific data. This cases report cannot serve as the answer to all the questions raised. It does, however, set the basis for further research, data, and evidence regarding PRP implementation in clinical practice to corroborate present findings in the clinical scenario.