Abstract

Leukocytoclastic vasculitis (LV) is one of the most common types of vasculitis. The pathology can be caused by infection, systemic autoimmune conditions, malignancies or medication. Leukocytoclastic vasculitis caused by medication represents 20% of the total cases. Several drugs can produce this pathology such as: antibiotics, antihypertensive, NSAIDs, antifungals, antivirals, immunosuppressive, and blood-thinning medications, among others. Methotrexate, antimitotic and immunosuppressive medication, is used for the treatment of illnesses such as vasculitis, malignancies, psoriasis and rheumatoid arthritis as a disease-modifying treatment. Until now, there are rare cases reported in the literature of LV secondary to the trial of methotrexate. The case of a 57 year old male patient is presented. The patient presented biopsy confirmed LV after daily administration of methotrexate as psoriasis disease treatment.