Objective: To study matrix metalloproteinase-3 (MMP-3) and Osteopontin (OPN) levels and correlations of MMP-3 and OPN with bone metabolic markers and bone mineral density (BMD) in postmenopausal Chinese women.
Methods: MMP-3、OPN、osteoprotegrin (OPG), Osteoprotegrin ligand (OPGL) of 120 postmenopausal Chinese female volunteers was measured using ELISA. BMD were measured using dual energy X-ray absorptiometry. According to the criteria of WHO, women were divided into 3 groups, such as normal, osteopenia and osteoporosis group.
Results
OPN concentrations were significantly higher in osteoporosis (56±20) ng/ml than normal (26±11) ng/ml (P
Matrix metalloproteinase-3; Osteopontin; Bone mineral density; Postmenopausal; biomarker