Abstract

This article explains dire need of highly effective drugs as most of the antibiotics are either failed to do action as microbes have developed multiple resistance. This article pertains with new innovative methods of synthesis or development of new drug, its delivery, biological interactions and safety measurements. It also sketches out important views to have potential drug molecules to minimize health concerns, enhancement of biosafety, fastest analytical and bio-analytical diagnostics. It also explains combination of multifunctional nano scale system, synthesis of enzyme inhibitors, chemo selective conjugates, synergistic combinatorial drugs, epigenetic therapy to obstruct metabolic pathways in microbes that could control pathogenicity. It also explains use of carbon-based nano materials, various metal complexes are used forinhibition of tumor growth and progression. This article shortly emphasize new polymeric molecules i.e. dendrimers, composite drugs, drug stabilizers, conjugates and carriers, pharmacophore which have great therapeutic value. Modern therapeutics needs molecular recognition of a ligand by specific receptors on cell surface, modifiers and carriers are in high need. Heterocyclic compounds are good antimicrobial and anticancer agents as they show wide spectrum of biological activities. Antimicrobial peptides (AMPs), critical components of the innate immune system, are widely distributed throughout the animal and plant kingdoms. Animal toxins can be used as drug templates, these natural molecules specifically target ion channels and receptors of both the central and peripheral nervous system, interfering with action potential conduction and/or synaptic transmission. These could be used for treatment of infectious diseases and cancer. Cheminformatics is used to design new drugs with help of computer, simulations and In Silico testing of drugs is done that has reduced a range of problems in the field of medicinal chemistry. Development of new effective drugs and disease control is a greater task because of multiple drug resistance. It could be solved by using natural compounds as drug molecules by making some modifications and additions to them. Drug must be of low cost so that under privileged class can easily get a treatment with new novel drug molecules, it will help us to fight against drug resistance.