Abstract

Breast cancer (BC) is the most leading disease which is common against women. Its treatment process requires special attention due to disadvantages of conventional methods such as limited therapeutic efficacy, side effects, cytotoxicity, drug resistance and low chances of quality survival. In order to rectify these demerits of conventional system nanocarriers system has been introduced. Various types of nanocarriers such as inorganic and organic polymeric, targeted modified system are used in the nanotreatment of breast cancer. Nanocarriers are the combination of various approached for treating disease. Nanocarriers are able to reduce cytotoxic effect of the anticancer drugs by enhancing cancer cell targeting in contrast to conventional system. This review summarizes broad information about breast and various types of nanocarriers such as polymeric micelles, liposomes (Thermosensitive, Immunoliposomes and pH sensitive liposomes), dendrimer, carbon nanotubes, Nanoparticles(Gold nanoparticles, Mesoporous Silica NPs, PLGA nanoparticles, Metallic nanoparticles, Solid lipid nanoparticles (SLNs), Nanostructured Lipid Carriers (NLC) Silver nanoparticles), Microemulsion, Nanofibers, Carbon dots, Quatum dots, Exosomes, Polymerosomes, Nanoshell, fullerene, hydrogels along with its published research work and application in Breast Cancer Therapy. Paper also emphasizes about the Receptor based drug therapy, Immuno-therapy and Radiation therapy for BC management.This review objects to provide a better understanding of these advancing novel method of cancer treatment and the main issues and key considerations for a rational design of nanocarriers used in combinational delivery of different synergistic anticancer agents.