Abstract

Psychosis in children is rare and can be challenging to treat. Treatment-resistant psychosis is particularly difficult to manage and may have underlying organic causes that are often overlooked. This case series presents two children with psychosis secondary to undiagnosed vitamin B12 deficiency, who were unresponsive to multiple antipsychotic medications. Both cases showed rapid resolution of symptoms following B12 supplementation. These cases emphasize the need for clinicians to consider vitamin deficiencies, particularly in patients with refractory psychiatric symptoms, and highlight the importance of early diagnosis and individualized treatment.