Abstract

Transferosomes are specialized lipid-based vesicles designed to improve drug delivery through the skin. Their unique flexibility allows them to penetrate the skin’s protective barrier more efficiently than traditional transdermal systems. Transferosomes combine the characteristics of liposomes and niosomes because they contain liposomes (phospholipids and cholesterols) and niosomes as components (non-ionic surfactants; edge activators). As a result, they are referred to as the first generation of elastic liposomes. However transdermal drug delivery is difficult due to the presence of the skin’s protective barrier, transferosomal drug delivery overcomes all obstacles due to its unique characteristics, such as its ultra-deformable vesicular nature. Transdermal drug delivery systems (TDDS), which are self-administrable and non-invasive, can improve bioavailability and patient compliance by bypassing first-pass metabolism. Vesicular-based TDDS have attracted a lot of attention in recent years because they’re designed for controlled, efficient, and targeted drug delivery. One of these delivery technologies, transpersonal-based formulations, has grown in popularity due to its ability to achieve all of the desired criteria and quality