Abstract

One essential metabolic process that breaks down glucose to produce ATP is glycolysis. Metabolism is severely disrupted by enzyme deficits in this route, including those that impair pyruvate kinase, phosphofructokinase, or hexokinase. The generation of energy can be hampered by these inadequacies, which can result in symptoms varying from lactic acidosis to exhaustion and cramping in the muscles. Knowing the function of particular glycolytic enzymes and the deficits in them helps with accurate diagnosis and efficient treatment of a variety of metabolic illnesses. In disorders linked to glycolysis, this understanding is essential for creating tailored therapies and enhancing patient outcomes.