Abstract

Niosomes are the new drug delivery system in which the solution is enclosed in a vesicle that is made of non-ionic surfactant. Niosomes are formations of vesicles by hydrating a mixture of cholesterol and non-ionic surfactants. It can be employed to transport both lipophilic and amphiphilic drugs. Niosomes have a flexible structural characterization and are biodegradable, biocompatible, and non-immunogenic. The primary goal of this review is to examine how noisome technology is applied to treat various diseases like cancer, leishmaniasis, and inflammatory diseases. Niosomes offer promising research opportunities and benefit both the pharmaceutical and research communities. Niosomes are physically and chemically unstable. Niosomes are unilamellar and multilamellar. Niosomes are prepared by the ether injection method, sonication technique, handshaking method, and from proniosomes method etc. Several factors affect the formation of niosomes and the factors are nature and type of surfactant, cholesterol content, and charge, the temperature of hydration, composition of membrane, etc. This review article focuses on the structure and type of niosomes, composition of niosomes, methods to prepare niosomes, factors, and applications of niosomes.