Abstract

The presence of active functional groups amino (-NH2) and hydroxyl groups (-OH) in their simple and unique structure, amino alcohols are very important drugs for the treatment of heart related diseases. Orciprenaline is moderately selective β2- adrenergic receptor agonist and a bronchodilator has importance to use in relaxing the airway muscles and to improve breathing for patients suffering from asthmatic or bronchitis problem. As due to the specific and proper spatial orientation of active groups to react with specific receptors (β2-receptor) enantiomer of β-blockers generally (S)-(−)-enantiomer shows about 50-500 fold higher pharmacological activities as compared to its mirror image. In the current review paper attempts are being done on the enantiomeric resolution of orciprenaline by using liquid chromatographic techniques and also deals with the application of: thin layer chromatography by direct method using specific chiral selector as chiral impregnating reagent, and certain chiral inducing reagents and by applying suitable mobile phases. Direct high-performance liquid chromatography using chiral stationary phase columns and indirect high-performance liquid chromatography using chiral derivatizing reagents for resolution of enantiomers of orciprenaline also incorporated in the present review paper.