Abstract

Addiction, a multifaceted disorder, poses significant challenges to public health worldwide. This mini review explores the neurophysiological underpinnings of addiction, with a focus on the role of reward circuitry and dopaminergic pathways. Methodological approaches such as animal models, human neuroimaging studies, and genetic/epigenetic analyses are examined to provide insights into addiction etiology and pathophysiology. Understanding the neurophysiological mechanisms of addiction informs the development of targeted pharmacological interventions and personalized treatment strategies. Moreover, these insights aid in crafting effective public health policies to address substance abuse. Integrating neurophysiological perspectives into addiction research and clinical practice is crucial for mitigating its societal impact. This review highlights the importance of interdisciplinary research in understanding addiction and developing targeted interventions.