Abstract

The purpose of the current study was to assess how doxorubicin treatment affected the heart and liver oxidative stress indicators in female Wistar rats. For in-vivo study, ten female albino Wistar rats were divided into two groups (n=5), control group and doxorubicin treated group. GSH, MDA levels and SOD, GST activities in heart and liver were measured in order to evaluate various oxidative stress markers. The tissue histology of the heart was examined. Results of the in-vivo rats study show that doxorubicin induces oxidative stress by decreasing the level of GSH level and increasing MDA level, SOD and GST activities in the DOX group compared to the control group. Furthermore, in comparison to the control group, DOX caused histological changes in the heart cells in the DOX group. This study concludes that doxorubicin treatment causes oxidative stress in the heart and liver of rats, which is detrimental to those organs.