Abstract

The complex and dynamic process of regenerating devitalized tissue was investigated using methanolic leaf extracts of Acacia bark, Mangifera indica, to support its long-standing use as a wound healer. To assess the wound healing activity at various doses of povidone iodine (5%) as the standard medication, five sets of six albinos Wister rats were employed in each model. Tensile strength, histological changes, and the rate of wound contraction were used to measure wound healing. The results show that, in compared to control and standard povidone iodine, experimental animals fed mg kg of ethanolic extract had a fast rate of wound contraction and larger wound breaking strength. By showing that the formulated extract has significant wound healing properties as measured on the 0, 4, 8, 12 and 16th days, i i.e. 232.21 ±5.8 (0%), 182.8 ± 4.2 (14.85%), 229.21 ± 5.2 (65.5%), 14.03 ± 2.9 (91.9%),2.7 ±1.04 (98.8%), the current study’s findings support the use of the extract in traditional medicine. Its use in conventional medicine is justified since its active components can accelerate wound healing.