Abstract

Nitrogen-containing heterocyclic compounds with five members are called pyrazoles. Derivatives of pyrazole have been used extensively in fluorescent compounds, agricultural chemicals, and colors. Nucleus can be found in pharmaceutical products across a range of therapeutic categories. Many researchers have been interested in studying the chemical and biological skeleton of this nucleus because of the diversity found in the biological field. The various synthesis techniques and pharmacological characteristics of pyrazole derivatives are highlighted in this review. Research on the biological activity and synthesis of pyrazole derivatives, conducted by numerous scientists worldwide is published. Because of its significant diversity in biological activity, pyrazole and its derivatives has become a prominent scaffold that has caught the interest of medicinal chemistry researchers. Almost all pharmacological activities are found in pyrazole and its derivatives, which are regarded as an important pharmacological active scaffold. Meanwhile, target structures known as pyrazole derivatives have been created and have shown a wide range of biological functions, including anti-inflammatory, anti-tumor, anti-viral, anti-microbial, anti-hepatotoxic, antioxidant, hypoglycemic, anti-convulsant and anti-proliferative. The newly synthesized compound structures were validated using elemental analysis, mass spectrum investigations, 1H and 13C NMR, FT-IR, etc. The results of published studies on the synthesis and biological activity of pyrazole derivatives are compiled in this review.