Abstract

In the health care system nanoparticles gain a lot of attention due to its vast advantages over other formulations. Various types of nanosystems are used for drug delivery such as polymeric nano-particles (NP), solid lipid NP, and liposomes. But they have some inherent limitations like drug leakage, low biocompatibility, use of specific drug molecule that is being enumerated in the literature. Drug-loaded lipid Polymer Hybrid Nano-Particles (LPHNP) is intentionally created for resolving all the constraints of conventional nano systems. The pros of both polymer and lipid NP are rendered in LPHNP. The release of water-soluble drugs is restricted by it due to its structure as the polymeric center of the structure is coated by the lipid. This brings about the augmented efficiency of trapping. Thus, oil or water-soluble drugs can be encapsulated ingeniously when creating lipid polymer hybrid nano-Particles (LPHNP). The development of hybrid polymer materials can avoid the synthesis of new molecules, which is an overall expensive process that can take several years to get to the proper elaboration and approval. Thus, the combination of properties in a single hybrid system can have several advantages over non-hybrid platforms, such as improvements in circulation time, structural disintegration, high stability, premature release, low encapsulation rate and unspecific release kinetics. Thus, the aim of the present review is to outline a rapid and well-oriented scenario concerning the knowledge about polymer-hybrid nanoparticles as well as requirements for the choice of drugs, lipids, polymers, disparate production techniques, various applications of lipid polymer HNP in gene delivery, cancer therapy, together with antibacterial therapy, are deemed in the proposed study