Abstract

Kaposi’s sarcoma is a vascular tumor associated with HHV-8. Clinically, there are classical, AIDS-related epidemic, endemic and iatrogenic types. Local, interventional and systemic treatments are available depending on the type of disease, extent and severity of lesions. However, there is no consensus on optimal treatments and this causes difficulties in treatment selection. Topical treatments such as alitretinoin, timolol, imiquimod, silver nitrate application, laser and surgery can be used. In systemic treatment, chemotherapeutics, immune modulators and antiviral agents can be used. Apart from these, successful results have been reported with treatments such as mTOR inhibitors, immune checkpoint inhibitors, PD-L1 inhibitors. In addition, treatments targeting enzymes such as methyltransferase, RNase and nitric oxide synthase are promising.