Abstract

Cannabis intoxication is associated with number of physical and mental health possibilities with consequent social costs. Nevertheless, little consideration has been given to the examination of likely pharmacological interactions in this situation. Research was done on the PubMed, Lilacs, and Scielo online databases using the terminologies cannabis, intoxication, psychosis, anxiety, and treatment which involved of case reports and controlled clinical trials and are obtainable according to interventions targeting the physiological, psychiatric, and cognitive symptoms provoked by cannabis. The pharmacological interventions reported in these studies included beta-blockers, anti arrhythmic agents, antagonists of CB-1 and GABA-benzodiazepine receptors, antipsychotics, and cannabidiol. Although scarce, the evidence on pharmacological interventions for the management of cannabis intoxication suggests that propanolol and rimonabant are the most effective compounds currently available to treat the physiological and subjective effects of the drug. Additional studies are necessary to establish the real effectiveness of these two medications, as well as the effectiveness of other candidate compounds to counteract the effects of cannabis intoxication, such as cannabidiol and flumazenil.