Abstract

Breast cancer is the most common malignancy in women, and it is highly curable if diagnosed at an early stage. Present study was designed to identify prognostic factors for early stage and locally advanced breast cancer patients in Gujarat. This retrospective study (n=100) was conducted on patients visiting Bharat Cancer Hospital and Research Institute, Saroli, Surat, Gujarat. Data were collected by the case report forms and analyzed for the age, menstrual status, risk factors, axillary nodal status, tumor size and type, therapy, and hormonal receptor status. Response and survival rate due to the therapy were also analyzed according to the different age groups. The breast cancer is more found in female patients more than 50 year of age (54%) and patients with post-menopausal status (64%). The risk factors like personal history, family history, proliferative benign breast disease and first child birth after age of 35 years are observed in the present study. Majority of patients are found with invasive type of ductal carcinoma with N1 axillary lymph node involvement (86%) and size of the tumor (T1) between 2 cm to 5 cm (67%). All patients are treated with surgery with adjuvant treatment like Neoadjuvant chemotherapy (41%), Post-Chemotherapy (18%), Biological therapy (15%) and Hormonal therapy (8%). Out of 100 patients, 78% and 92% were Estrogen Receptor positive and Progesterone Receptor positive status. HER-2 positive status is found in 75% which is comparatively high than negative (7%) and unknown (17%) status. In different age group of patient’s the disease free survival is more than the recurrence and death. This study highlights the importance of various prognostic factors and hormone receptor status evaluation in different age groups that will aid in therapeutic intervention. This study also determined various treatments, treatment response and

survival rate in different age group of breast cancer patients.