Abstract

Tall cell carcinoma with reverse polarity is an exceptional subtype of papillary carcinoma of breast. Neoplasm characteristically displays IDH2 p.Arg172 hotspot genetic mutation and enunciates minimal malignant metamorphosis. Cytological examination singularly disseminated or nests and papillary configurations of tumour cells impregnated with grooved nuclei. Microscopically, solid aggregates, circumscribed nodules or attenuated, abridged papillae composed of cuboidal, columnar or tall, columnar cells pervaded with abundant, eosinophilic cytoplasm and bland nuclei situated upon the apical pole are observed.