Abstract

Ovarian cancer is the most fatal gynecological disease and arises from epithelial cells, stromal cells, and germ cells. The incidence of ovarian cancer increases with age, with a peak incidence at the age of 50-60 years. Almost 60% of the women who develop ovarian cancer will lead to death. Some of the risk factors for ovarian cancer involve hysterectomy, pelvic inflammatory disease, and polycystic ovarian syndrome. In this review, we discussed various animal models which accurately represent the cellular and molecular changes associated with the initiation and progression of human ovarian cancer and have significant potential to facilitate the development of better methods for the early detection and treatment of ovarian cancer. Also, we reviewed the reliability and limitations of the existing tumor models.