Abstract

The area under the curve (AUC) is developed to quantify the total rise in blood glucose during an oral glucose tolerance test (OGTT) in clinics. Similarly AUC is also used in the assay of new agent(s) development for diabetes in animals. In clinics variations in fasting plasma glucose of each case have been suggested to rule out by subtracting the baseline showing at the 0 min during OGTT. Then the incremental area under the curve (iAUC) value is developed and it is also applied in the calculation of the glycemic index (GI) of foods in nutrition. Additionally iAUC has ever been used to rule out the variations in fasting plasma glucose between genetic animals and the wild-type littermates. However it is limited in the cases that received acute treatment only. Taken together we suggest that modification of the baseline values shall be careful. The basal glucose level and/or fasting plasma glucose must include in the calculation of AUC during OGTT in animals received a chronic treatment which is widely applied in the pharmacological assay. Therefore the treated method is mainly associated with the application of iAUC or not.