Statistically significant molecular features have been identified that determine the anticholinesterase activity of a number of analogs of aminostigmine. It is shown that the affinity constant is closely related to the pseudopotential of the molecule. Regression equations were obtained that determine changes in the bimolecular inhibition constant and carbamylation constant. The conditions for the possibility of creating effective drugs with low toxicity have been established.
Aminostigmine; Regression; Inhibitor; Cholinesterase; Enzyme; Affinity Constant; Statistical Criteria; Carbamylation Constant; Hydrophobicity; Information