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Pharmaceutical Sciences & Analytical Research Journal ISSN: 2640-6659
Research Article
A Comparative Study of How Exercise Influences Drug Metabolism and Pharmacokinetics in Human

Authors: Manjula Kumari VV, Mohammed Sheeba Kauser*, AL Prasanna Syamala Reddy and Shankar CM

Published: 2024-07-25
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Abstract

Understanding the interaction between exercise and drug metabolism is crucial for optimizing pharmacotherapy in physically active individuals. This study investigates the impact of acute aerobic exercise on the pharmacokinetics of a model drug in healthy human subjects.

Methods: Twelve healthy adults (6 males, 6 females) participated in this crossover study. Each participant underwent two separate sessions: one with moderate-intensity aerobic exercise (treadmill running) and one without exercise (control). Following standardized meals and rest periods, participants received a single oral dose of the model drug (e.g., caffeine). Blood samples were collected at specified time points over 6 hours post-dose to determine plasma drug concentrations using liquid chromatography-mass spectrometry.
Results: Exercise significantly affected the pharmacokinetic parameters of the model drug compared to the control condition. Exercise resulted in a faster absorption rate, evidenced by a shorter time to maximum plasma concentration (Tmax). Additionally, exercise increased drug clearance, as indicated by a higher apparent clearance (CL/F), and decreased the area under the plasma concentration-time curve (AUC). No significant differences in drug bioavailability were observed between exercise and control conditions.
Conclusion: These findings demonstrate that acute aerobic exercise alters drug metabolism and pharmacokinetics in healthy humans, potentially impacting drug efficacy and safety profiles. Clinicians should consider individual exercise habits when prescribing medications to ensure optimal therapeutic outcomes. Further research is warranted to elucidate the underlying mechanisms and extend these findings to various drug classes and patient populations.

Keywords

Metabolic Syndrome; High Fructose Diet; Oxidative Stress; Biochemical Markers