Abstract

Objective: The aim of this study was to explore the efficacy of pretreatment of insulin resistant PCOS patients by metformin alone and by metformin plus myo-inositol (MI) before using oral ovulation inducing agents for induction of ovulation. Materials and methods: This prospective experimental study was conducted in Infertility Care and Research Center (ICRC) Ltd between January and December 2018. One hundred and sixty insulin resistant (PCOS) patients of primary infertility, who failed to ovulate by tab letrozole 10 mg/day for 5 days and tab glucocorticoid 0.5mg every alternate day for 5 days, were recruited for insulin sensitizer drug. By using lottery 80 patients received only metformin for 12 weeks and 80 patients received both metformin and MI with folic acid for 12 weeks. After 12 weeks, we gave same drugs for ovulation induction at which patient was resistant before using insulin sensitizers. Follicular tracking was done to observe ovulation. Patients were advised for timed sexual intercourse. Viable pregnancy was confirmed by observing cardiac pulsation by ultra-sonogram. Student’s t test and Chi square test were done for statistical analysis. A p value of