Abstract

Background and Objectives: Peptic ulcers are increasingly reported as a challenging disease in clinical settings. The exact pathology is obscure and probably multifactorial, including acidity, infection, erosion, stress, and poly pharmacy. Hence, curably treatment is lacking. The present study aimed to assess the dose of indomethacin that can induce ulcer. Methods: Thirty albino Wistar rats were used for the pilot study, they were subdivided into three groups, each group contain 10 rats, all were indomethacin treated groups of different doses (low dose indomethacin 25 mg/kg, moderate dose indomethacin 30 mg/kg, and high dose indomethacin 35 mg/kg) and according to microscopic examination; 30 mg/kg of indomethacin was used to induce gastric ulcer for the main study. Stomachs were excised from the rats bodies, and examined macroscopically. Then the stomach tissues were processed for histological examination. Results: A dose of 30mg indomethacin has successfully induced gastric ulcer. Conclusion: Titration of the dose give indication about the therapeutic dose of indomethacin which could induce no ulcer in stomach.